When comparing Mu4e vs Alpine, the Slant community recommends Mu4e for most people. In the question“What are the best native e-mail clients for Linux?” Mu4e is ranked 9th while Alpine is ranked 11th. The most important reason people chose Mu4e is:
The UI is designed to allow for quick keystrokes to get around and is pretty clean. Header View: !(http://www.djcbsoftware.nl/code/mu/mu4e-2.png) Message View: !(http://www.djcbsoftware.nl/code/mu/mu4e-3.png)
Ranked in these QuestionsQuestion Ranking
Pro Can write rich text emails
Using the (beta) org mode, Mu4e can compose fully rich text emails.
Pro Built-in Autocomplete
Doesn't require you to import address books for autocomplete, learns from your emails just like Gmail.
Heavy actions never block emacs, unlike most other emacs email clients.
Pro Fully Search Based
Mu4e has no folders or other organizational tools, rather it relies on very fast search queries to help you find your mail.
Pro Extremely user-friendly
Pro Can use the built-in text editor or can be integrated with another text editor
Alpine comes with pico, a lightweight text editor which can also be used as a standalone tool. It can also be integrated with vi, vim, emacs, etc... if the user prefers to do so.
Pro On-screen contextual help
Alpine has contextual help that can be displayed on-screen. Removing the need to consult the man pages every time you forget a command or how to do something inside it.
Con Updates are not frequent
Alpine is not updated frequently. This means that new features, bug fixes or security updates come much later than in other email clients.