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Add to SafariWhen comparing Mu4e vs Zimbra Web Client, the Slant community recommends Mu4e for most people. In the question“What are the best self-hosted webmail clients?” Mu4e is ranked 4th while Zimbra Web Client is ranked 12th. The most important reason people chose Mu4e is:
The UI is designed to allow for quick keystrokes to get around and is pretty clean. Header View:  Message View: 
Question Ranking
Pros
Pro UI optimized for speed
The UI is designed to allow for quick keystrokes to get around and is pretty clean.
Header View:
http://www.djcbsoftware.nl/code/mu/mu4e-2.png
Message View:
Pro Asynchronous
Heavy actions never block emacs, unlike most other emacs email clients.
Pro Fully Search Based
Mu4e has no folders or other organizational tools, rather it relies on very fast search queries to help you find your mail.
Pro Can write rich text emails
Using the (beta) org mode, Mu4e can compose fully rich text emails.
Pro Built-in Autocomplete
Doesn't require you to import address books for autocomplete, learns from your emails just like Gmail.
Pro Full-featured collaboration solution
If you are looking for an alternative to Gmail, look no further than Zimbra. While not a complete document solution it does have some document features as well.
Cons
Con Heavy and monolithic
Zimbra doesn't much work with its host platform as much as it brings its own copies of utilities. If you want something small and "plays well with others" integratable...this is not it. Too heavy to run on a RaspberryPi if you're looking for something for just a few users.
Con Linux only
There is no installator for Windows
