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Add to SafariWhen comparing Mu4e vs AfterLogic WebMail, the Slant community recommends Mu4e for most people. In the question“What are the best self-hosted webmail clients?” Mu4e is ranked 4th while AfterLogic WebMail is ranked 5th. The most important reason people chose Mu4e is:
The UI is designed to allow for quick keystrokes to get around and is pretty clean. Header View:  Message View: 
Question Ranking
Pros
Pro UI optimized for speed
The UI is designed to allow for quick keystrokes to get around and is pretty clean.
Header View:
http://www.djcbsoftware.nl/code/mu/mu4e-2.png
Message View:
Pro Asynchronous
Heavy actions never block emacs, unlike most other emacs email clients.
Pro Fully Search Based
Mu4e has no folders or other organizational tools, rather it relies on very fast search queries to help you find your mail.
Pro Can write rich text emails
Using the (beta) org mode, Mu4e can compose fully rich text emails.
Pro Built-in Autocomplete
Doesn't require you to import address books for autocomplete, learns from your emails just like Gmail.
Pro Branding
In admin panel you can supply separate logos for login screen and for top-left corner of main interface.
Pro Multilanguage, with autodetection
Interface is available in over 30 languages. WebMail attempts to determine your system language and open the interface in it.
Pro Autorefresh
Configurable autoreload of email message list every N minutes
Pro Drag 'N Drop
Mails can be dragged into a different folder, contacts can be added into group, events in calendars can be tossed around, etc. - all with drag 'n drop.
Pro Mobile version of interface
Open WebMail on your iOS or Android device to get a simplified mobile interface. And when run on iOS, it'll offer you to get iOS profile with settings for mail access, contacts and calendar sync.
Pro Plugins infrastructure
A few dozens of plugins, some of those created by community. Plugins are placed into data directory so they survive upgrades easily.
Pro External services integration
Twitter, Facebook, Google and Dropbox are supported. With last two, you can access their file storage; and you can use social account credentials to log into your WebMail acct.
Pro Sync with Windows, iOS, Android, etc.
Offers syncing through DAV with mobile devices, there are also mobile apps and Windows sync client.
Pro Multiple accounts
In WebMail Pro each user can have multiple accounts added to switch between them and use them separately.
Pro Available in multiple editions
In addition to commercial WebMail Pro, simplified free opensource WebMail Lite is available. Also there are MailSuite Pro (which is basically WebMail Pro integrated with mailserver software) and Aurora, extended with groupware features.
Pro Simple
Cons
Con Horrible instructions
They don't proceed in any logical order, omit significant steps and contain useless stuff like:
"Another critical part of setting up the product is configuring database settings. It's assumed that you already have a database created, fill in the connection details, press Save, then you can Create Tables."
Con Not responsive at all
3 layers of Mail section overlying each other. Totally not supported by mobile. Very bad mobile interface.
Con No Unified inbox
They planned it for a while, but for now, it's still working with one account at a time.
Con No CardDAV support in free version
CardDav Sync is not available in AfterLogic WebMail Lite, which is the free version.
