When comparing Mu4e vs Evolution, the Slant community recommends Evolution for most people. In the question“What are the best native e-mail clients for Linux?” Evolution is ranked 4th while Mu4e is ranked 9th.
Ranked in these QuestionsQuestion Ranking
Pro Can write rich text emails
Using the (beta) org mode, Mu4e can compose fully rich text emails.
Pro Built-in Autocomplete
Doesn't require you to import address books for autocomplete, learns from your emails just like Gmail.
Heavy actions never block emacs, unlike most other emacs email clients.
Pro Fully Search Based
Mu4e has no folders or other organizational tools, rather it relies on very fast search queries to help you find your mail.
Pro Great integration with Gnome environment
Pro Manages contacts, tasks, calendar and memos as well
Pro Clean interface with 2 layout variants
Going to View > Preview has the option of switching between "Classical View" and "Vertical View".
Pro Good support for Google's services
Pro Supports exchange servers
Evolution is one of the few Linux desktop e-mail clients that's supports exchange servers.
Pro Excellent GPG support
The integration with GPG is excellent. You can sign, encrypt, decrypt, authenticate and verify GPG signatures and GPG signed/encrypted email messages. All of that is just a setting away.
Pro HTML rendering is great
Of the many email clients available on GNU/Linux, Evolution has the best HTML renderer. It renders HTML and the entire email content exactly like it would appear on a full blown web browser. Not many email clients are capable of doing that.
Con RAM heavy
Very heavy on RAM usage.
Con Only available on Linux
If you have to switch to another platform for whatever reason, you will need to search for a different email client.
Con Tied to Gnome
Pulls in Gnome.
Con Can't choose different settings for each mail account
Settings have to applied to all mail accounts.