When comparing Handlebars.js vs Mustache.js, the Slant community recommends Handlebars.js for most people. In the question“What are the best JavaScript templating engines?” Handlebars.js is ranked 2nd while Mustache.js is ranked 4th. The most important reason people chose Handlebars.js is:
Handlebars is available as a JavaScript library, a [Django](https://github.com/yavorskiy/django-handlebars) module as well as [Java](https://github.com/jknack/handlebars.java), [Ruby](https://github.com/MSch/handlebars-ruby), [Scala](https://github.com/mwunsch/handlebars.scala), [.Net](https://github.com/rexm/Handlebars.Net) & [PHP](https://github.com/zordius/lightncandy) libraries, which means you can use it for frontend and backend templating in the language of your choice.
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Pros
Pro Clean syntax
Handlebars's syntax is very readable and easy to understand.

Pro Clear separation of logic and markup
If something is not within {{
and }}
, it's not Handlebars. As a result, Handlebars "weaves" through HTML, instead of trying to become an invalid extension of it.
Pro Copy/Paste code from the internet
Examples for Bootstrap or other CSS frameworks are always in HTML. With Handlebards you can just copy and paste the examples in your code. With something like Pug (Jade) you have to convert the HTML to Pug (Jade) first.
Pro Easy to use for templating things other than HTML
The syntax allows the output to be any text and does not contrain the user to HTML output only. There are examples of handlebars being used to produce SQL, javascript and other programming language code.
Pro Easy to use any template also as partials
Templates may be nested and reusable parts can be factored out.
Pro Compiled rather than interpreted templates
Handlebars.js allows you to pre-compile your templates so that the loading time at the client end could be reduced when your templated page is loaded.
Pro Mustache compatible
You can import Mustache templates and add extra functionality, that's provided by Handlebars, on top of them.
Pro Good global helpers support
Pro Logic-less
By design, logic-less templates force you to separate concerns thus helping you avoid future problems with refactoring. It also allow templates to be used with multiple programming languages without changes.
Pro Good paths support
With Handlebars.js you can create bindings with variables inside any path in your application.
Pro Easy to define extensions
With a few lines of code, a new extension (control or templating function) can be implemented. It will be called by the compiled templates.
Pro Clean syntax
Mustache provides you with a clean and easy to understand syntax. Having a syntax that is readable is always a huge plus, since this means easier maintenance and code readability in the future.
Pro Available in lots of languages
Available in a wide variety of languages including Ruby, JavaScript, Python, C++, Scala, Go, Julia, Swift and more. See the full list here.

Pro Lightweight
Mustache is easy to deliver. If you need more features down the road, you can switch to handlebars, which is a superset of Mustache.
Pro Logic-less
By design logic-less templates force you to separate concerns thus helping you avoid future problems with refactoring. It also allow templates to be used with multiple programming languages without changes.
Pro Server side support
Mustache.js has multi-language server side support, which essentially means you can use mustache based templates on languages other than javascript. (like if your server-side was built on Java you could still use Mustache.js)
Pro Popular
This would mean that you'll have a large community to help you out if you run into any problems.
Pro Can be compiled
Mustache templates can be compiled to JS files, so that they can be directly loaded.
Cons
Con Hard to use documentation
Although the documentation exists and is fairly comprehensive, it's not always clearly written, and there is no search capacity.
Con Handlebars are still an HTML code
Handlebars use the standard HTML syntax with its own {{tags}} for templating. This doesn't add much to readability or design speed.
Con Using partials is cumbersome
"In order to use a partial, it must be registered" using some JavaScript method attached to some global variable.
Con Not much editor support
Handlebars.js doesn't seem to have many text editors that support things like auto-complete, syntax highlighting or error checking for it.
Con Does not play well with Angular.js
.. or any framework where you wish to compile handlebars.js template to the template understanable by the framework.
Con Basic tasks are difficult
Mustache js's attempts at making some things simple makes them so easy that they're almost difficult. That is the case with some basic tasks like figuring out how to apply css to shade odd/even rows on your template based content.

Con Bested by Handlebars in many ways
Handlebars being an extension of Mustache bests it in both speed and power. It adds additional features to Mustache which make writing templates easier and faster.
Benchmarks have also shown that Precompiled Handlebars renders in about half the time of Mustache and the rewritten Handlebars (current version) is 5 to 7 times faster than Mustache.
