When comparing PyGObject / Python3 vs pyglet, the Slant community recommends pyglet for most people. In the question“What are the best Python GUI frameworks/toolkits?” pyglet is ranked 10th while PyGObject / Python3 is ranked 12th. The most important reason people chose pyglet is:
Since pyglet is so tightly woven with OpenGL it allows the support of drawing in 3D.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Works particularly well on Linux, as many desktops use Python and GObject
GObject is a 'C' library with bindings to many other languages, so can be widely used.
Nice GTK.UIManager function to produce a menu system from a string.
Pro 3D support
Since pyglet is so tightly woven with OpenGL it allows the support of drawing in 3D.
Pro Cross-platform
Works with Windows, Linux, and OS X.
Pro Written in pure Python
A small advantage, but being a core Python developer, it may be the best to stick to the roots and develop with pyglet as it is able to compile using other Python interpreters.
Cons
Con Doesn't work well if you're targetting Windows, even though there probably is a binding
Not very close to Windows look and feel.
Con Small community/popularity
There is a decent amount of documentation and API to go along with pyglet, but in terms of community support there seems to be very little.