When comparing NanoGUI vs Tkinter, the Slant community recommends NanoGUI for most people. In the question“What are the best cross-platform GUI toolkits?” NanoGUI is ranked 4th while Tkinter is ranked 20th. The most important reason people chose NanoGUI is:
Any control can be custom drawn.
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Pros
Pro Looks nice and it's easy to extend
Any control can be custom drawn.
Pro Free for commercial use
Pro Included in the standard Python library
You probably already have it, since it's included in the standard Python distributions.
Pro Easy to learn and get productive with
TkInter is a small library with a gentle learning curve compared to what’s out there. It has a straightforward API and is often the go-to choice for building quick GUIs for Python scripts.
Pro Building executables is less complicated
Compared to other GUI libraries, building executables for TkInter applications are simpler because TkInter is included in Python and has no other dependencies. This results in less complicated packaging requirements and smaller binary size.
Pro Fast
Cons
Con Lacks a bunch of common widgets
Con No advanced widgets
TkInter does not come with advanced widgets out of the box (e.g. date picker).
Con Not good looking
You need a lot of code to make it look good.
Con No reliable UI builder available
There is no tool in the same league as Qt Designer (PyQt) for TkInter.