When comparing Knockout vs Handlebars.js, the Slant community recommends Handlebars.js for most people. In the question“What are the best client side templating libraries?” Handlebars.js is ranked 2nd while Knockout is ranked 6th. The most important reason people chose Handlebars.js is:
Handlebars is available as a JavaScript library, a [Django](https://github.com/yavorskiy/django-handlebars) module as well as [Java](https://github.com/jknack/handlebars.java), [Ruby](https://github.com/MSch/handlebars-ruby), [Scala](https://github.com/mwunsch/handlebars.scala), [.Net](https://github.com/rexm/Handlebars.Net) & [PHP](https://github.com/zordius/lightncandy) libraries, which means you can use it for frontend and backend templating in the language of your choice.
Ranked in these QuestionsQuestion Ranking
Pros
Pro Easy data binding
Knockout uses HTML5 data attributes to bind HTML elements to data objects in javascript. This allows more work to be done by the framework rather than requiring you to specify where data should be bound in the javascript. The data binding is very intuitive as the bindings are done within the HTML itself in the location it should be bound.
Pro Easy to learn
Has a low entry barrier and an easy learning curve. It's especially easy to learn for beginners.
Pro Built in templating
Bindings in Knockout can also be used to control the generated structure of the HTML. There are bindings provided to allow for iteration and conditionals. The structure of the html reflects the structure of the data so iterative elements are bound to arrays in the data model. Having the HTML structure maintained by bindings keeps the templating simple, easy to read, and maintain.
Knockout also allows for string based templating so you can use whatever templating library you prefer.
Pro Legacy browser support
Supports a large number of browsers, including IE6.
Pro Great documentation
The excellent tutorials with built-in exercises are a great learning experience, even for people without prior MVVM and data binding experience.

Pro Lightweight and plays nicely with other libraries
Pro Dynamic models help with keeping the code simple and clean
Models in Knockout can be watched to keep the page data up to date by using observable objects. The observables notify Knockout when data is changed and automatically updates the page when this happens. By having Knockout maintain this relation, it keeps the front end code cleaner and simpler, and by enforcing a consistent pattern with observables the methodology can be more robust.
Pro Very flexible
One can do a lot of things and it keeps self references and other types of loops under control.
Pro It's only a library
Knockout does one thing, and does it well. It doesn't try to take on more than one area. It does MVVM data binding and that is it.
Pro Simple manageable modules
Using components is a great way of breaking up large modules into simpler ones.
Pro Clean syntax
Handlebars's syntax is very readable and easy to understand.

Pro Clear separation of logic and markup
If something is not within {{
and }}
, it's not Handlebars. As a result, Handlebars "weaves" through HTML, instead of trying to become an invalid extension of it.
Pro Copy/Paste code from the internet
Examples for Bootstrap or other CSS frameworks are always in HTML. With Handlebards you can just copy and paste the examples in your code. With something like Pug (Jade) you have to convert the HTML to Pug (Jade) first.
Pro Easy to use for templating things other than HTML
The syntax allows the output to be any text and does not contrain the user to HTML output only. There are examples of handlebars being used to produce SQL, javascript and other programming language code.
Pro Easy to use any template also as partials
Templates may be nested and reusable parts can be factored out.
Pro Compiled rather than interpreted templates
Handlebars.js allows you to pre-compile your templates so that the loading time at the client end could be reduced when your templated page is loaded.
Pro Mustache compatible
You can import Mustache templates and add extra functionality, that's provided by Handlebars, on top of them.
Pro Good global helpers support
Pro Logic-less
By design, logic-less templates force you to separate concerns thus helping you avoid future problems with refactoring. It also allow templates to be used with multiple programming languages without changes.
Pro Good paths support
With Handlebars.js you can create bindings with variables inside any path in your application.
Pro Easy to define extensions
With a few lines of code, a new extension (control or templating function) can be implemented. It will be called by the compiled templates.
Cons
Con Slower than others when amount of objects grows
Knockout has a bad performance when the dealing with large amount of objects. You can see more here.
Con Can become complex once the application grows large
Knockout leaves the application structure to the developer and it can become quite complex and unmanageable in the hands of a beginner once the application grows large and complex.
Con Two way binding requires a little extra work
When allowing users to edit existing data, the two-way binding of observables means you'll need to have to save original values before they're edited, to make comparisons or revert if the user cancels the action.
Con Hard to use documentation
Although the documentation exists and is fairly comprehensive, it's not always clearly written, and there is no search capacity.
Con Handlebars are still an HTML code
Handlebars use the standard HTML syntax with its own {{tags}} for templating. This doesn't add much to readability or design speed.
Con Using partials is cumbersome
"In order to use a partial, it must be registered" using some JavaScript method attached to some global variable.
Con Not much editor support
Handlebars.js doesn't seem to have many text editors that support things like auto-complete, syntax highlighting or error checking for it.
Con Does not play well with Angular.js
.. or any framework where you wish to compile handlebars.js template to the template understanable by the framework.
