When comparing Guix vs Slackware, the Slant community recommends Slackware for most people. In the question“What are the best Linux distros that don't use systemd?” Slackware is ranked 2nd while Guix is ranked 16th. The most important reason people chose Slackware is:
Uses stable, plain-vanilla packages from upstream.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Atomic package management without bloated init/supervision systems
For those with a clear focused concept of what is wanted, after building, the build can be replicated in a blink on countless machines. Both GUIX and shephard are complex but also a breath of fresh air.
Pro Secure rootless installation
While the whole system can be configured using a declarative file with sufficient privileges. Users can install any package in their own local profile with a single command without root.
Pro A truly advanced operating system
Solves modern problems of software management in one concise, coherent, and fully integrated system.

Pro Stable
Uses stable, plain-vanilla packages from upstream.
Pro Strong adherence to UNIX Principals
Pro Ideal to learn more of Linux
Follows the original Linux roots. It still sees Linux as a free clone of UNIX so the distribution tries to be UNIX-like.

Pro Package management
Uses standard tar archives with shell scripting as packages.
Pro One more distro which is init based
Some users don't like to install systemd based distros because they increase booting and processing speed.
Pro Oldest surviving Linux distro
Besides Debian (which was first released in August 1993), it is the oldest still maintained Linux Distribution and was first released in July 1993.
Pro Super fast
Pro No systemd
Cons
Con Not for newbies, neither for seasoned professionals, unless raging against conformity with artful purpose
Con Not user-friendly
It is made to be KISS (keep it simple, stupid), so you have to do everything by hand.
Con Large size live ISO
One needs to vain 3GB+ data for downloading one slackware ISO.
Con Narrow repos
Doesn't offer the same amount of options as other distros do.
Con Niche/small community
Slackware is its own niche and has a small community.
Con Very slow release cycle
Hasn't updated in 3+ years.
Con Dependency issues
When it comes to dependencies, Slackware shows more issues than many other distros.
