When comparing PyxleOS vs Piskel, the Slant community recommends Piskel for most people. In the question“What are the best pixel art / sprite editors?” Piskel is ranked 7th while PyxleOS is ranked 26th. The most important reason people chose Piskel is:
WPiskel is HTML5-based so it works in any modern browser.
Specs
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Pros
Pro Customizable UI
The user interface has support for color themes that are both built-in and user-definable. The canvas transparency tile can also be modified to the user's liking.
Pro Lightweight
The size of the .jar binary is a little less than 1 MB, making the application very lightweight.
Pro Includes a useful text editor
PyxleOS features a basic text editor module that can be used for note-taking or modifying a file that follows encoding standards.
Pro Secure, Java-based cross platform binary
PyxleOS can be used on any OS that runs Java 8 and above.
Pro Free and open source
The download of PyxleOS is free and all source code is available at a public repository at GitHub.
Pro Works in any browser
WPiskel is HTML5-based so it works in any modern browser.
Pro Animation support
Piskel includes onion skinning, exporting to sprite sheets or gifs, defining frame rate, and present live playback.
Pro Sleek interface
It is also easy on the eyes.
Pro Very simple for beginners
Once you get the hang of it its a very powerful tool
Pro Offline versions available
The downloadable version of Piskel (built with node-webkit) is available for Windows, Linux, and Mac OS X.
Pro Easy to use lighten and darken tool
With the click of a button you can create amazing shading.
Pro Enough tools to be powerful
It has enough tools to be powerful, but not too many to put off beginners.
Pro Open source
Piskel is licensed under Apache License, meaning that the user can use the software for any purpose.
Pro Has a straight foreward tile view mode
... so you can instantly see the result while drawing tiles
Cons
Con Undo/redo unavailable
Undo/redo functions are not available in PyxleOS.
Con Lacks a number of features
Due to it being relatively new software, PyxleOS is somewhat buggy and underfeatured.
Con Lacks a true resizing tool
There doesn't seem to be any decent tool in Piskel for an easy stretch or shrink. The only ways possible is resizing the whole image or importing and image and shrinking it from the export tool.
Con No button for undo
Have to use ctrl+Z.
Con Rotation is limited
Rotation is only made in predefined angles. Does not support variable rotations or mouse based rotation. Does not support rotating selected areas, only frames-layers.
Con Shading by hand
Shading can be difficult.
Con Doesn't work well with drawpads
In the online tool you can't draw lines at all, yet using a graphic tablet, being in the offline version controls are pretty chunky and everytime you start drawing a line, the screen flickers black for a short period of time.