When comparing Slax vs Pop!_OS, the Slant community recommends Pop!_OS for most people. In the question“What are the best Linux distributions for desktops?” Pop!_OS is ranked 16th while Slax is ranked 54th. The most important reason people chose Pop!_OS is:
If you're a fan of flat desktop interfaces reminiscent of Material design on Android, you'll like the theme that comes as a default in Pop! OS. The desktop and title bars all use a bright turquoise theme that makes the interface feel happy and borderline retro-chic. I found it to be like something you'd find printed on a ringer t-shirt.
Specs
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Pros
Pro Persistent changes
Changes you make in the configuration persist if you run from USB.
Pro Pretty fast to boot up
It was considerably fast to turn on when booting from cd.

Pro Modules
Standard tar archives plus some simple shell scripting produces modules that you can load dynamically into the OS for added apps and functionality.
Pro Modern desktop

Pro Small footprint
About 200mb, but with a full KDE4 environment and loads of useful apps.
Pro Pop! makes GNOME look really good
If you're a fan of flat desktop interfaces reminiscent of Material design on Android, you'll like the theme that comes as a default in Pop! OS. The desktop and title bars all use a bright turquoise theme that makes the interface feel happy and borderline retro-chic. I found it to be like something you'd find printed on a ringer t-shirt.
Pro User-friendly installer
The visually appealing and easy to use installer makes dual booting as easy as it can be.
Pro Ready to play games, out of the box
If you still miss how easy it was to just click-install and play games in Windows, Pop! will give you that similar expectation.
Pro Nice gnome theme dy default
Has nice gnome theme looks really good.
Pro A separate NVIDIA version
Most linux distros seem to hate Nvidia's graphics cards e.g. Fedora and OpenSUSE. System76 have decided to be kind. They have decided to form a good relationship with Nvidia fans and Nvidia itself. By creating a separate installation media that is dedicated for providing support to Nvidia's graphics cards. Even going as far as putting Nvidia's driver updates on Pop!_Shop for users to easily access and install.
Pro Optimized for modern hardware
Whereas normally, to use a brand new computer with a Linux OS, you would typically try to use unstable and sometimes buggy drivers - or struggle without hardware support until a stable release comes along.
Pro Made by a hardware seller
System76 is a hardware company. It configures machines to ship with Linux pre-installed. This means its entire business model centers around delivering a quality desktop Linux experience.
As a result, the company pours more attention onto the desktop. It can fix visual issues and may be able to provide a smoother overall experience than you would have installing a different version of Linux on your machine yourself. Providing Pop!_OS also empowers System76 to make certain fixes for users directly rather than having to coordinate with Canonical or the broader Ubuntu community.
Cons
Con Overly complicated HDD/SSD installation
While it has a nice layout Slax's lack of an installer tool like Tinycore's just can't be justified. It seems strange that it comes built in with programs that some users may not want, yet it doesn't have an easy way to install it. Due to its heavier use of RAM, built in software, and lack of an installer its hard to choose it over TC.
Con Works slowly on old computers
Con Infrequent releases
Since Slax is maintained by only one person, releases are not that frequent. So it may take a while to get bug fixes or new features once you start using it.
Con 64-bit only
Some older PCs still have 32 Bit processors. This limitation will be a major con for those who use an older PC since they will not be able to install, run it in a VM or live media
