When comparing TexturePacker vs 2D Toolkit, the Slant community recommends TexturePacker for most people. In the question“What are the best tools to create sprite atlases for Unity 2D?” TexturePacker is ranked 1st while 2D Toolkit is ranked 2nd. The most important reason people chose TexturePacker is:
Drag and drop sprites onto the canvas, change the settings, then output.
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Pros
Pro Simple Interface
Drag and drop sprites onto the canvas, change the settings, then output.
Pro Multiple Atlas Output Formats for Unity
There are three different outputs for Unity to read the atlas; JSON, Texture2D, and 2D Toolkit.
Pro Good documentation
The documentation for the toolkit is well written and there are video tutorials as well as an active community.
Pro Includes source code
No need to pay more to get access to the source code.
Pro Pixel-perfect camera
Pixel games in the style of 8 or 16 bit systems need to have each pixel uniform on the screen which 2D Toolkit supports with a camera component.
Pro Add colliders in the atlas editor
Choose from either a box, sphere, or mesh collider that will output as either a 3D or 2D collider in Unity.
Pro Create different resolutions of atlas
2D Toolkit allows for different sizes of atlas from 1x, 2x, or 4x which can be changed depending on platform resolution.
Pro Built to work inside Unity
2D Toolkit is an editor extension so users don’t have to leave the Unity engine for tile mapping.
Pro Create Atlases within the tool
Create sprite sheets for tiles to save draw calls and to keep tilesets organized.
Pro Supports the Tiled TMX Format
Create tilemaps in Tiled and implement with 2D Toolkit.
Cons
Con Pure functionality in the free version, you can't even set margins
The full price is too high for such a simple app.
Con No direct integration
TexturePacker is an external third party application with no Unity Inspector interface.
Con Doesn't integrate with Unity's Sprite system
2D Toolkit provides a completely proprietary sprite implementation. Though it can be used alongside Unity's 2D systems, the two are completely separate and require different code to utilize.