Ranked in these QuestionsQuestion Ranking
Pro Abstracts tmux and screen with a single user interface.
Pro Adds OS dashboard alerts
byobu has support for OS alerts when an event happens.
Pro apt-get or yum install byobu
If neither tmux nor screen are already installed, installs tmux. Both screen and tmux can be installled at same time. Switch between either easily.
Con Adds only a relatively superficial abstraction on tmux or screen
Byobu still uses GNU Screen or tmux as the backend, so from a usability perspective it doesn't add much in terms of new functionalities, instead it only adds a layer of abstraction on top of them.