Ranked in these QuestionsQuestion Ranking
Pro Very flexible
Pyramid can be used for creating small applications quickly and easily, but it also powers up large enterprise-scale applications such as Dropbox.
Pro Persistence agnostic
Either NoSQL and SQL (including SQLAlchemy plugin).
Pro Comes with security included
Includes authorization and authentication with multiple backends.
Con The great number of options it offers can become intimidating
One of Pyramid's greatest drawbacks is that it requires a lot of set up in the beginning of a project. This can feel overwhelming and can keep people away from using it.