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You set it up once and from then it runs in the background whenever you are not using your computers (or at specified times).
Pro Supports multiple backup destinations
You can set up different files/folders to back up to specific places.
Pro Differential and incremental file backup
CrashPlan updates only that part of the file that has changed, saving bandwidth and time.
Pro Unlimited online storage
The $5/mo individual plan and the $12.50/mo family plan gets you unlimited cloud storage.
Pro Allows custom encryption keys
Custom 448 bit user-provided encryption key can be used to encrypt the backed up data in the cloud.
Pro Users can order a physical copy of their data
They will send you an external hard drive to your house.
Pro Unlimited revision history
CrashPlan saves all previous versions of a file.
Con Home edition discontinued
CrashPlan's home edition will be shut down on October 23, 2018. They are no longer accepting new signups or subscription renewals.
Con Popular features (local backup and trusted offsite backup) no longer available
Con Heavy client
The BackupClient is based on Java and therefore a lot more memory-intensive than most other backup solutions