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You set it up once and from then it runs in the background whenever you are not using your computers (or at specified times).
Pro Unlimited online storage
The $5/mo individual plan and the $12.50/mo family plan gets you unlimited cloud storage.
Pro Differential and incremental file backup
CrashPlan updates only that part of the file that has changed, saving bandwidth and time.
Pro Supports multiple backup destinations
You can set up different files/folders to back up to specific places.
Pro Users can order a physical copy of their data
They will send you an external hard drive to your house.
Pro Allows custom encryption keys
Custom 448 bit user-provided encryption key can be used to encrypt the backed up data in the cloud.
Pro Unlimited revision history
CrashPlan saves all previous versions of a file.
Pro Free for DIY setups
If you wish to backup to your own server or a local disk, CrashPlan is free.