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Pro Beginner-friendly defaults
The default configuration includes everything except for system files to be backed up. That also includes external USB drives. This will work for most people. It can, of course, be customized to each person's liking.
Pro Excellent restoration performance
Backblaze creates a zip file of all your files for you to download, thus decreasing the amount of data you need to download and increasing the speed of the download since it's one connection instead of multiple that need to be opened and closed for a list of files.
Pro No filesize of traffic restrictions
There are no limitations of file size or amount of data you can upload. The $5/mo plan gets you unlimited cloud storage.
AES encrypted files are transferred over a secure SSL connection.
Pro Users can order a physical copy of their data
You can have a flash drive or an external hard drive delivered to you. They cost $99 and $189 respectively.
Pro Download any backed-up files from any web browser
Some backup services like Carbonite require a client to be installed to restore files. Backblaze allows you to login and download any or all files from a web browser, meaning it also serves as an ad-hoc cloud storage platform.
Con No Linux support
There's no Linux client for Backblaze.
Con Backblaze does not support network (NAS) drives
If you use a thing like Drobo, Backblaze will not back it up.