Binding of Isaac is an indie arcade roguelike with a unique, somewhat twisted, premise.
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Pros
Pro Tons of replayablity
Random levels, random items, random enemies, every game is new, exciting and challenging.
Pro One of a kind game
One of the best arcade roguelikes (or roguelikes, if you're a purist) out there. Difficult to beat completely and oh so very satisfying. Gazillions of unlocks, secrets, bosses, power-ups and item combinations. Limited co-op (BoIR only). The game can be genuinely terrifying and dark, especially if you take a moment to ponder what's really going on with its backstory and characters.
Pro Addictive gameplay
With an arcade style feel and a fairly quick play through, the game makes it easy to sit down and play for hours. Addicting could best describe the gameplay, something that the player can get lost in without getting overly complicated.
Pro Very easy to learn and play, while it doesn't get boring
While it is very easy to learn and play, it is still a difficult game to beat and therefore has a lot of replayability.
Pro Great Soundtrack
The soundtrack from the original and the new version fits the game really well and is extremely characteristic
Cons
Con It's creepy
The game to be put nicely is not really scary but just plain creepy. Definitely not a game recommended for children.