When comparing pygame vs TIC-80, the Slant community recommends pygame for most people. In the question“What are the best 2D game engines?” pygame is ranked 16th while TIC-80 is ranked 49th. The most important reason people chose pygame is:
Pygame uses Python as its scripting language. Python is widely considered one of the easiest languages to grasp even for beginners.
Specs
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Pros

Pro Easy Python syntax
Pygame uses Python as its scripting language. Python is widely considered one of the easiest languages to grasp even for beginners.
Pro Very easy to understand
The API is very straightforward.
Pro Good canvas system
Pygame has a drawing system that allows the user to create and draw on an unlimited number of canvases.
Pro All tools in one place
The app contains tools for coding, sprite editing, map editing, sfx and music editing.
Pro Free
Free version already includes most features but a paid version is available.
Pro Retro-styled and restricted environment
Pixelated Software with a good retro style.
Pro Many Scripting languages' supported
Use awesome scripting languages like: Lua, Wren, Moonscript, JS, Ruby, etc.
Pro Export
Exports easily to Windows, Windows-XP, mac, Linux and HTML.
Pro Noob underdog
You can imagine this engine Shiva Lua scripting language making 2d side scrolling Megaman style games a Bandai trademark.
Cons

Con Deathly slow
Con Nonexistent community
No good forums, wiki, or other ways to reach other Pygame developers.
Con Very basic
Pretty much just a wrapper for SDL.
Con Pygame is a multimedia framework, not a game engine
Physics, AI and networking are not supported.
Con Messy documentation
The docs are messy, and some basic functions are infuriating to work out. There's even some places in the documentation where it's clearly wrong about how a method is called/what the arguments really do.
Con Outdated
Pygame uses a really old version of SDL and is missing some of the features developed for SDL2.
Con Hasn't been updated in years
Hasn't been updated in years.
