When comparing MonoGame vs Genome2D, the Slant community recommends MonoGame for most people. In the question“What are the best 2D game engines?” MonoGame is ranked 9th while Genome2D is ranked 49th. The most important reason people chose MonoGame is:
Support for iOS, Android, Mac OS X, Linux, Windows (both OpenGL and DirectX), Windows 8 Store, Windows Phone 8, PlayStation Mobile, PlayStation 4, Xbox One, Nintendo Switch, and the OUYA console with even more platforms on the way.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Cross-platform
Support for iOS, Android, Mac OS X, Linux, Windows (both OpenGL and DirectX), Windows 8 Store, Windows Phone 8, PlayStation Mobile, PlayStation 4, Xbox One, Nintendo Switch, and the OUYA console with even more platforms on the way.
Pro Open source
All the code is available to you ensuring you'll have the ability to make changes when you need to or even port to whole new platforms.
Pro Well-known and documented API
The framework implements the XNA 4 API, so games made in XNA can be ported to other platforms using this. This was the same API used by the Xbox Live Indie Games platform so there's lots of documentation online for it.
Pro Managed code
By leveraging C# and other .NET languages on Microsoft and Mono platforms you can write modern, fast, and reliable game code.
Pro Good community
The community MonoGame has to offer is helpful and mature.
Pro Performance on desktop
The performance on desktop platforms matches that of C++, but you still get all the pleasant features that C# has to offer.

Pro Lightning fast
It's the fastest gpu-based framework out there for flash. It's beautifully optimised. It has very low rendering latency, low level OpenGL calls that other tech simply cannot do (ie Unity) due to Stage3D, and thus can render a lot more data quicker
Pro Cross-platform mobile, desktop and web
Supports Windows, Mac OS X, Linux, iOS, Android, Web and native Flash.
And with the HTML5 export, it also potentially supports development for the Wii U :)
Pro Haxe!
Haxe is a strictly typed programming language that saves development time but still compiles high performance executables, and can build for tons of different platforms (flash, c++, html5, java, c#, etc.)
Pro Access to direct draw features
Has access to direct draw features so you can make you own rendering structures (scene graphs etc).
Pro Automatic dynamic batching
Automatically batch geometries with dynamic batching techniques (by using constant buffers).
Pro Component based architecture
Cons
Con Slow rate of updates
Versions 3.9 is overdue by a year, and version 4.0 is set to release in 2040.
Con Non-Windows tools are a bit funky
Monogame support for Xamarin Studio or Monodevelop is a bit shaky especially for library references. Only good non-Windows IDE compatible with MonoGame is Rider and that costs money & isn't open-source.
Con Lacks documentation
The API documentation is minimal, there's not many tutorials and the ones that are there are very small and only cover the basics. If you want to learn how to properly use it, you have to ask the community or read the source code and figure it out.
Con Not too many games to showcase it
Con Slow development rate
