When comparing CRM32Pro SDK vs uScript + Unity3D, the Slant community recommends CRM32Pro SDK for most people. In the question“What are the best 2D game engines?” CRM32Pro SDK is ranked 91st while uScript + Unity3D is ranked 97th. The most important reason people chose CRM32Pro SDK is:
EditorDPF: resource editor for managing images, tiles, sprites, sounds, etc. of your game MSTE: tile-based parallax scrolling engine with support to Tiled Qt .TMX files SetupProject: customized configuration system.
Specs
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Pros

Pro Great tools included
EditorDPF: resource editor for managing images, tiles, sprites, sounds, etc. of your game
MSTE: tile-based parallax scrolling engine with support to Tiled Qt .TMX files
SetupProject: customized configuration system.

Pro Cross-platform
CRM32Pro works on Windows, Linux and MacOS X.

Pro Open source and free
CRM32Pro is licensed under LGPL license with full access to the source code on the website.

Pro Automatically generates nodes for third-party script assets
uScript's nodes are a visual representation of actual code blocks, and it takes advantage of C#'s reflection capabilities to automatically create nodes for any scripts it finds in your project, regardless of the source. This makes it inherently compatible with pretty much everything.
Custom nodes can also be created by hand, for cases where the automatically created ones contain more elements than they actually need.

Pro Versatile flow diagram script model
Modeled after UDK's Kismet (the predecessor to UE4's Blueprint), uScript's scripts resemble flowcharts where each box represents a function or value, with connections between them representing program flow. This provides a better at-a-glance indication of game logic than a simple list of events, and makes complex behaviors easier to accomplish.

Pro Generates C# source code
Nodes are translated directly to C# files in your project. This is great for learning to code, and also for advanced users who can use uScript for fast prototyping and then further optimize the scripts if necessary.
Cons
Con Not as beginner friendly
C/C++ skills and general knowledge of SDL and basic game programming is required in order to get all the benefits.

Con Not that easy to use
It's a lot more complicated compared to something like Playmaker. Same tasks take a lot more time.
