When comparing Visual Studio with the Python Tools extension vs PyScripter, the Slant community recommends PyScripter for most people. In the question“What are the best Python IDEs or editors?” PyScripter is ranked 15th while Visual Studio with the Python Tools extension is ranked 38th. The most important reason people chose PyScripter is:
PyScripter is a lightweight Python IDE.
Specs
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Pros
Pro Autocompletion based on variable types
Has smart autocompletion based on variable types
Pro Cloud storage through VS Online
Your Visual Studio Online account gives you a place to store your code, backlog, and other project data with no servers to deploy, configure, or manage.
Pro Web based interface to track project progress
In agile development teams one really needs features such as product backlogs where you can assign features to team mates and track their progress on them. VS provides a web based interface for you to track your team's complete progress on the project.
Pro Lightweight
PyScripter is a lightweight Python IDE.
Pro Easy to use
Covers the needs of advanced users (thread debugging, unit testing etc.).
Pro Superb for interactively developing scripts
When you run a program, the context is automatically available in the Python interpreter afterwards, without having to set breakpoints.
Pro Easy to set up
No configurations needed. Just download and code.
Cons

Con Windows only
Visual Studio is only available on Windows, though there is now a cross-platform derivation of Visual Studio named Visual Studio Code. It is has less features and is more of a code editor than an IDE.

Con Proprietary
Visual Studio is a proprietary software.
Con Windows only
Available for Windows only.
Con Noticeably unstable since v.4
Frequently hangs/freezes, esp. when debugging.
Con Refactoring is not that easy
In Pyscripter, refactoring pretty much leans on traditional dumb find-and-replace.
