When comparing Sylphis3D vs pyglet, the Slant community recommends pyglet for most people. In the question“What are the best game engines for Python?” pyglet is ranked 7th while Sylphis3D is ranked 8th. The most important reason people chose pyglet is:
Since pyglet is so tightly woven with OpenGL it allows the support of drawing in 3D.
Specs
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Pros
Pro 3D support
Since pyglet is so tightly woven with OpenGL it allows the support of drawing in 3D.
Pro Cross-platform
Works with Windows, Linux, and OS X.
Pro Written in pure Python
A small advantage, but being a core Python developer, it may be the best to stick to the roots and develop with pyglet as it is able to compile using other Python interpreters.
Cons
Con Small community/popularity
There is a decent amount of documentation and API to go along with pyglet, but in terms of community support there seems to be very little.