When comparing Diagrams.net vs Microsoft PowerPoint, the Slant community recommends Diagrams.net for most people. In the question“What are the best mockup and wireframing tools for websites?” Diagrams.net is ranked 6th while Microsoft PowerPoint is ranked 22nd.
Specs
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Pros
Pro Rich functionality for a web-based application
Pro Integrates with multiple cloud storage services
Draw.io offers saving files directly to services such as Google Drive, OneDrive or Dropbox along with saving to to computer.
Pro Real-time collaboration
Pro Great flexibility customizing text labels
Pro Completely free
Pro There is also a Desktop version
Pro Good list of different output formats
Draw.io supports export for PNG, GIF, JPEG, PDF, SVG, HTML, and XML.
Pro Internet Explorer 6-8 and touch device support
Draw.io works with every browser (even IE 6) without plugins.
Pro De facto standard
PowerPoint is the most widely used presentation app.
Pro Lots of free templates
Because PowerPoint is so common, there are tons of free templates found within the program or online.
Pro Excellent integration with Windows
Cons
Con Import from Visio .vsd is useless
Even simple diagrams get all scattered.
Con Behaves strangely for certain diagram types
For example the snapping function for arrows doesn't work properly for the sequence diagram template.
Con Is poor at handling animation-heavy presentations
Adding too many animations might cause it to slow down quite significantly, as well as on older versions more complicated animations might not work very well.