When comparing Tkinter vs pyglet, the Slant community recommends Tkinter for most people. In the question“What are the best Python GUI frameworks/toolkits?” Tkinter is ranked 3rd while pyglet is ranked 10th.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Free for commercial use
Pro Included in the standard Python library
You probably already have it, since it's included in the standard Python distributions.
Pro Easy to learn and get productive with
TkInter is a small library with a gentle learning curve compared to what’s out there. It has a straightforward API and is often the go-to choice for building quick GUIs for Python scripts.
Pro Building executables is less complicated
Compared to other GUI libraries, building executables for TkInter applications are simpler because TkInter is included in Python and has no other dependencies. This results in less complicated packaging requirements and smaller binary size.
Pro Fast
Pro 3D support
Since pyglet is so tightly woven with OpenGL it allows the support of drawing in 3D.
Pro Cross-platform
Works with Windows, Linux, and OS X.
Pro Written in pure Python
A small advantage, but being a core Python developer, it may be the best to stick to the roots and develop with pyglet as it is able to compile using other Python interpreters.
Cons
Con No advanced widgets
TkInter does not come with advanced widgets out of the box (e.g. date picker).
Con Not good looking
You need a lot of code to make it look good.
Con No reliable UI builder available
There is no tool in the same league as Qt Designer (PyQt) for TkInter.
Con Small community/popularity
There is a decent amount of documentation and API to go along with pyglet, but in terms of community support there seems to be very little.