When comparing pyglet vs uScript + Unity3D, the Slant community recommends pyglet for most people. In the question“What are the best 2D game engines?” pyglet is ranked 43rd while uScript + Unity3D is ranked 97th. The most important reason people chose pyglet is:
Since pyglet is so tightly woven with OpenGL it allows the support of drawing in 3D.
Specs
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Pros
Pro 3D support
Since pyglet is so tightly woven with OpenGL it allows the support of drawing in 3D.
Pro Cross-platform
Works with Windows, Linux, and OS X.
Pro Written in pure Python
A small advantage, but being a core Python developer, it may be the best to stick to the roots and develop with pyglet as it is able to compile using other Python interpreters.
Pro Automatically generates nodes for third-party script assets
uScript's nodes are a visual representation of actual code blocks, and it takes advantage of C#'s reflection capabilities to automatically create nodes for any scripts it finds in your project, regardless of the source. This makes it inherently compatible with pretty much everything.
Custom nodes can also be created by hand, for cases where the automatically created ones contain more elements than they actually need.
Pro Versatile flow diagram script model
Modeled after UDK's Kismet (the predecessor to UE4's Blueprint), uScript's scripts resemble flowcharts where each box represents a function or value, with connections between them representing program flow. This provides a better at-a-glance indication of game logic than a simple list of events, and makes complex behaviors easier to accomplish.
Pro Generates C# source code
Nodes are translated directly to C# files in your project. This is great for learning to code, and also for advanced users who can use uScript for fast prototyping and then further optimize the scripts if necessary.
Cons
Con Small community/popularity
There is a decent amount of documentation and API to go along with pyglet, but in terms of community support there seems to be very little.
Con Not that easy to use
It's a lot more complicated compared to something like Playmaker. Same tasks take a lot more time.