When comparing Pixelmator vs Pyxel Edit, the Slant community recommends Pyxel Edit for most people. In the question“What are the best pixel art / sprite editors?” Pyxel Edit is ranked 6th while Pixelmator is ranked 11th. The most important reason people chose Pyxel Edit is:
Tiles can be animated within Pyxel Edit, with "onion skin" frame overlays to assist in making smooth frame transitions.
Specs
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Pros
Pro Beautiful, easy to use UI
Pixelmator's interface is pleasant to look at, easy to use and specifically optimized for OS X users, making it very intuitive for long-time Mac users.
Pro Feature rich
Not only does Piexelmator provide easy to use tools that you should expect in any image editor, it also has rare tools such as layer styles, liquify tools and OS X optimized, fast image manipulation engine among others.
Pro Supports layer styles
Layer styles allow non-destructively applying effects to a layer.
Pro Powerful effects
Dozens of visual effects available, easily discovered from the visual Effects Browser, broken into categories. Effects have interactive dialogs and live preview.
Pro Multiple-display support
Pixelmator can be used across any number of monitors.
Pro Loads quickly
Gives you common image editing capabilities almost instantly.
Pro Great performance
Pixelmator's image engine is specifically optimized for use with Macs, providing one the best performance results available on OS X.
Pro Inexpensive
Pixelmator costs just $30 on the App Store. Additionally, it often comes bundled with other software that you might also find useful bringing the price down.


Pro Supports animations
Tiles can be animated within Pyxel Edit, with "onion skin" frame overlays to assist in making smooth frame transitions.


Pro Intuitive UI
Pyxel Edit is widely acclaimed for its ease of use.

Pro Tileset extraction
Given an image and specified tile dimensions, Pyxel Edit will extract a tileset with no duplicate tiles. This mostly works for flat images though. If you feed Pyxel "finished maps" you will still get a lot of duplicates.


Pro Tilemap serialization support
Tile-based images (maps) built in Pyxel Edit can be serialized via XML or JSON for easy import elsewhere.
Pro Cheap compared to others
For only $9 (£6), this is one of the cheapest but also one of the best pixel editors out there.
Pro Live tile-update
Instantly see if your tiles are tileable and/or seamless and fix it easily.
Pro Indexed tiles can be used for reusing objects in animations
Cons
Con development has stopped -- developer has stated 8/20 that a new version will be released soon
Con Lacks some tools
Con No Linux version
There is no Linux version of the editor.


Con Free version lacks features
The free version of Pyxel Edit is an outdated beta. It does not receive updates.
Con Proprietary, closed-source software
This software does not respect your freedom.

Con Mac version is dependent on Adobe Air
The OSX version of the application requires Adobe Air to run.
