When comparing RPG in a Box vs RPG Creator, the Slant community recommends RPG in a Box for most people. In the question“What are the best beginner game engines for making a top-down JRPG?” RPG in a Box is ranked 13th while RPG Creator is ranked 15th.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro All-in-one dev environment
Pro Cross-platform
Games can be created for any platform that supports HTML5.
Cons
Con Non standard scripting language
Has it's own "Bauxite" scripting language.
Con HTML5 is very dependent on browser performance
Theoretically all browsers should run HTML5 pretty much the same way, but thats not always the case. Something that worked fine on Chrome, for instance, might malfunction on Firefox (or vice versa). And there's nothing the devs of RPG Creator can really do about it, but to hope next Firefox update might fix it. Internet Explorer is not even recommended.
Add to that the fact that exporting to mobile or desktops rely on these sort of stripped down versions of web browsers (Node webkit, Crosswalk, Ejecta) that you pack with your game, and you can have a real headache if you're trying to make your game work properly through multiple platforms.
Con Abandoned
RPG Creator's last release was January 03 2014.