When comparing Tiled vs Blender, the Slant community recommends Blender for most people. In the question“What are the best 2D animation tools for game development?” Blender is ranked 5th while Tiled is ranked 9th. The most important reason people chose Blender is:
Blender is licensed under the GPL. Some Blender modules such as the Cycles rendering engine are licensed under the Apache 2.0 license.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Multi-platform
Not everyone uses the same operating system and why should they? Tiled supports Windows, Mac, and Linux so you can work in any environment you like. Also with daily builds you get to stay ahead of the curve!
Pro Free and open-source
Using the GPL license means you get to use this software free and are free to make changes to it as you see fit.
Pro Unlimited layers
Sometimes you need 20 layers to make something epic. Tiled lets you create as many layers as you need.
Pro Use shell commands
Setup shell commands within Tiled so you can setup workflows for each of your games.
Pro Supports Orthographic and Isometric tiles
Whether you want a straight on look at your world or a slightly skewed one Tiled has you covered.
Pro Terrains
Setup boarders with your tilesets so making tiles provide the correct connections automatically. This feature will speed up your level creation.
Pro Auto-mapping
One of the coolest things is to create rules so you can automate the mapping process. Want to have certain tiles to always have a collider? Simply make a rule for it and it'll do it automatically. Speed up your mapping process with this feature.
Pro Many engines already have support
A big list of engines already have support for Tiled provided by those in the community. See if the engine you use is already on the list.
Pro Can create colliders and triggers within editor
Tiled makes it easy to setup triggers and colliders with its vector tools or you can set up a tile that’s invisible in your game. Change collider/trigger properties so you can access them within your game.
Pro Tile size and image size do not have to match
Want to import a giant object but don’t want to split it up? Import it and place it the exact size you want it as one object.
Pro Properties
Create properties for your map, layers, tilesets, tiles, and objects. Have the flexibility you need to create the best levels for your game.
Pro Engine agnostic
Tiled provides an easy solution for tile maps for any engine even the custom engine you are now making. This makes Tiled a very versatile tool for 2D games.


Pro Free and open source
Blender is licensed under the GPL. Some Blender modules such as the Cycles rendering engine are licensed under the Apache 2.0 license.

Pro Wide import and export format support
Support lots of modern 3D formats including DAE and FBX - ideal for game developers.
Pro Has a powerful rendering engine
Blender runs the Cycles path tracing engine under the hood. Cycles is a very powerful rendering engine capable of full path tracing (light fall off, caustics, volumetrics). It is mostly compatible with OpenCL and CUDA rendering, and is implementing mycropolygon displacement features. The upcoming release has a viewport engine called EEVEE whereby you can see and interact with your work in render mode in real time!

Pro Python extensibility
Blender embeds Python 3, which can be used to write add-ons, tools, extend the interface, rig characters and automate tasks.

Pro Powerful animation suite
Blender provides a full rigging system, and automates animation by interpolating between keyframe positions.
Pro Supports both low-poly and hi-poly modeling

Pro Regular release schedule
Releases are made every ~3 months.
Pro Sculpting and 3D painting features
Although Blender's 3d painting and sculpting tools (mostly painting) are not at par with specialized software like Substance Painter, ZBrush, or Mari, it is more than capable of getting most jobs done if the user takes the time to learn and understand it.

Pro Includes video editing & compositing tools
Blender's node-based compositor has comprehensive video sequencing and post-processing features.
Pro Node based modeling support
Pro Keyboard shortcuts
Good keyboard shortcuts for everything. Keep your left hand on the keyboard and your right hand on the mouse.
Pro Very useful for a freelancer
It offers a round solution (it covers many areas and professional fields) for a freelancer, for free, constantly updated, very polished, and allowing high quality results that clients do require. After some learning, it becomes very useful for professional work.
Pro Has a large community
There's a huge community to help you get started immediately.
Pro Coherent and streamlined workflow / internal use logic
The trick with Blender is to get used to its usage philosophy, as it keeps consistent through all the application. Once you get it, every feature or addition is learnt naturally, almost effortlessly.
Pro Very versatile
You don't have to switch between software when you want to do different things. Because modeling, sculpting, composting, video editing etc can all be done in blender.
Pro Generative geometry using nodes
Cons
Con Must implement .tmx if your engine doesn’t support Tiled.
It’s not a huge deal but you do need to implement Tiled into your engine if you don’t have it. Don't be lazy just follow this guideline to get your game running. Must implement .tmx if your engine doesn’t support Tiled.
Con Too many possibilities, no unified workflow
The operations are not optimized enough for specific tasks.
Con The physics engine is a bit lagging behind, especially the destruction physics
Con Difficult learning curve
Blender has a history of being unintuitive, but the 2.8 overhaul made the program far easier for beginners to pick up, and changes continue to be made to further improve the experience. However, there is still a learning curve.
Con Not good for Industrial Design because it uses average vertex normals
You can not create a hard surface with a radius continuity degree along a surface using a specific radius value.
Con Vertex normal issues on edges after boolean operations.
After creating a simple boolean operation the vertex normals are broken. A lot of work to fix the issue and you loos surface continuity.
Con Bad vertex normal after boolean operations
Does not handle well polygon intersections. And need tweaking by hand points or adding average vertex normals via modifiers.
Con Does not handle NURBs
Is not capable of real hard surface for industrial design because is not able to reproduce surface continuity degree as a NURBs does and average vertex normal destroy surface radius.
Con Poor particle system
The Blender particle system can at times be a little limiting and finicky (and buggy) to get working. Even if it can get most straight forward jobs done, it is far from the most advanced system, and could benefit largely from advancements.
