When comparing OpenBOR vs GameFlow + Unity, the Slant community recommends GameFlow + Unity for most people. In the question“What are the best game engines for beginners and non-programmers?” GameFlow + Unity is ranked 26th while OpenBOR is ranked 33rd. The most important reason people chose GameFlow + Unity is:
It is almost like talking with Unity naturally. Actions in Unity can be coded using regular English more-so than with other game engines, which makes it much easier for beginners.
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Pros
Pro With a bit of tweaking, it's also possible to create a platformer
It's possible for a non-programmer who is comfortable with text-based designing to tweak the engine in order to create a platformer. Almost all the parameters needed can be found in the OpenBOR wiki, so it's easy to find anything a new developer needs.

Pro Great genre-specific engine
OpenBOR can quickly help create a good Beat-Em-Up game without programming.
Pro Great, supportive community
OpenBOR community is highly active and very helpful.
Pro Adds an abstraction layer that helps create the game logic
It is almost like talking with Unity naturally. Actions in Unity can be coded using regular English more-so than with other game engines, which makes it much easier for beginners.
Pro None of boxes and arrows, perfectly integrated into the workflow of Unity
Almost all visual scripting solutions for Unity are based on nodes, boxes and arrows, GameFlow changes this way of working incorporating actions blocks and actions using drag and drop.
Pro Excellent product
The developer supports the users quickly and with detailed responses. He is knowledgeable on the Unity API as well as developing videogames.
Pro Integrated in the Unity inspector
No windows apart, work with GameFlow from the own Unity inspector
Pro Can achieve in minutes what would take hours with classical scripting
Due to its innovative block system and without follow tutorials or look documentation will be able to create actions within five minutes in Unity.
Pro An effective advanced prototyping and scripting tool
GameFlow allows to complete a videogame in half an hour.
Cons
Con Text-based parametric editing
Heavy reliance on text-editing. No visual editor to edit characters and levels (although there are a few community-built ones that do the job).
Con The documentation is not very extensive
The documentation for GameFlow could use some work. It's not very extensive and it hardly covers everything needed to know to build a game.
Con Performance could be better for 2D
Performance can be a real issue with 2D games. Unity 3D is actually a 3D game engine, and drags a lot of overhead with it.
For mobile, one could never achieve the performance of more specialized 2D engines with Unity3D.
