When comparing Duality vs ct.js, the Slant community recommends Duality for most people. In the question“What are the best 2D game engines?” Duality is ranked 30th while ct.js is ranked 55th. The most important reason people chose Duality is:
The full source code is available on GitHub, where the framework is actively developed. All of the editor, core and plugin code is written in C#.
Specs
Ranked in these QuestionsQuestion Ranking
Pros

Pro Open source
The full source code is available on GitHub, where the framework is actively developed. All of the editor, core and plugin code is written in C#.

Pro Great editor
Duality includes a powerful visual editing system that can be used for previewing, integrating, editing and testing game content.

Pro Live reload of code and assets

Pro Very extensible
Because both Core and Editor are completely plugin-based, Duality not only incorporates a clean and modular design, but is also very extensible - even if it wasn't Open Source. In fact, most of the standard editing capabilities comes in form of Editor plugins.

Pro Built-in physics and lighting

Pro Friendly to version control systems
It can be configured to serialize all data in a text-based format, which has been structurally optimized for version control systems.

Pro Used in commercial projects
It has been used in a production environment without burning the place to the ground. Supposedly artist-proof editor workflow with an API for tailoring the system to fit your team.
Pro Beginner-friendly
ct.js is bundled with examples, docs, and easy to follow tutorials. Documentation and tutorials are available in a side panel on every screen.
Pro Skeletal animations with DragonBones support
You can import skeletal sprites and animations from DragonBones, which is also free. Skeletal animations are added to objects through code; developers can listen to marked events in animation, and ct.js automatically associates sounds in a DragonBones project with the game's assets.
Pro Good code editor
The built-in code editor comes with error checking, type checks, code completions accompanied with docs, multiple cursors support, and other modern features.
Pro Open source (MIT)
This means that no one will ever put any features behind a paywall and that you can reliably use ct.js in any projects without worrying about licensing. And you can hack on ct.js!
The repo is at https://github.com/ct-js/ct-js
Pro Tileset support
ct.js supports tiles in rooms, including collision checks and some extra editor tools, like bulk migration to a new tile layer or shifting by an exact value.
Pro WebGL and WebGL2 support
Starting with v1.0.0-next-1, you can now write WebGL games. WebGL support is based on Pixi.js.
Pro Modular approach
ct.js has a "Core" library that provides basic drawing functions, room and asset management, and mouse interactions. Any other functions are added to projects as "catmods", or simply modules. These modules can be enabled or disabled in one click, and can inject their code in different game loop stages, e.g. after drawing all the objects, leaving a room, or when a new object is created.
Pro Applicable to most genres
ct.js aims to be a general game engine and provides tools in making games of any genre.
Pro Dialogue and visual novel system with support for Yarn
A module ct.yarn allows developers to import a YarnSpinner project to create branching, data-driven dialogues and visual novels. An example is also bundled with ct.js.
The dialogue tree is made in a separate app, though.
Pro Real-time particle system editor
v1.3 brings a particle system editor, which displays a preview sprite for proper attachment of emitter to visual elements, and allows combining more than one emitter with different particles into one effect. With these, even the creation of complex, multi-step effects becomes easy. The editor comes with dozens ready-made textures for faster prototyping.
Cons
Con Visual Studio required
To have possibility for scripting you have to download entire Visual Studio and spend 10 GB of free space
Con Requires windows for development
Con Tile editing is a chore
No live brushes with automatic corner drawing, no fills or rectangular/linear placement. All tiles should be placed by hand, with a "Shift" key to place multiple tiles at once. This will make you ragequit if you want to make sophisticated RPG scenes :D
Con Slower than native games
JavaScript and WebGL are fast, but they will always lose in performance if compared to native games, so it may be a bad choice for graphics-heavy games.
