When comparing Spine vs Moho 12, the Slant community recommends Spine for most people. In the question“What are the best 2D skeletal animation tools?” Spine is ranked 2nd while Moho 12 is ranked 5th. The most important reason people chose Spine is:
Ranked in these QuestionsQuestion Ranking
Pro Integration libraries support most engines
Pro Simplified UI allows for an easy learning curve
No-nonsense workflow allows you to create your artwork in programs much better suited for the task like Illustrator and Inkscape for example, while Spine itself focuses only on the important task of skeletal animation.
Pro Allows for easy use of artwork from third party programs
Spine's developers provide scripts which makes exporting artwork from third party programs much easier to do.
Pro Community-driven feature roadmap
Esoteric Software maintains public Trello boards to help plan and prioritize feature additions.
Pro Funded via Kickstarter
Spine received resounding support from Kickstarter backers, beating its pledge goal by over 5 times.
Pro Easy to use interface
Quicker to animate and use than other similar products.
Pro Good community support
Lots of online forums, Facebook groups, YouTube videos, etc.
Pro Cheaper than Toon Boom and Adobe Products
Cheaper than Toon Boom and Adobe Products. People often complain about the price hike, but the pro version does go on sale, and even the full priced version is less than other insdurty standards on the market.
Pro It's better than any 2D animation software on the market for vector based animations
It beats Adobe Flash and Toon Boom at vector based animation. It has more features for 2D vector animations with it's integration with 3D mesh and bone rigs. Smart bone rigs create better animtions with less distortions then Toon Boom, and there are no bone rig animation options with Adobe Flash.
Con Professional Edition is expensive
Essential edition includes nearly all features, but IK Weights and Mesh Animations are not included in the Essential Edition.
Con No integration for some major engines
Spine does not directly support several popular 2D engines, including Construct 2, Clickteam Fusion, and GameMaker Studio. Unreal Engine and CryEngine also have no native modules.
Con Limited support for game engines
In most cases you'll have to export and edit sprite sheets. This will consume memory. Also, FBX file support is limited and not all features will run in Unity. Aside from Unity, there is no support for runtimes for video game engines. Also, many animation features such as vector integrated features will not export to Unity. Spriter, Spine, and Dragon Bones would be better options.