When comparing Demina vs Creature, the Slant community recommends Creature for most people. In the question“What are the best 2D skeletal animation tools?” Creature is ranked 7th while Demina is ranked 14th. The most important reason people chose Creature is:
One of Creature's strengths is its ability to assign motors on bones which will generate animations based on parameters set on the motors.
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Pros

Pro Straightforward tutorials
Denima's user interface is very simple, and the primary documentation is a simple walk-through of the workflow.


Pro Open source
Demina is a C#/XNA application hosted on CodePlex under the Microsoft Public License.
Pro Automated animation
One of Creature's strengths is its ability to assign motors on bones which will generate animations based on parameters set on the motors.
Pro Unity runtime always up to date
Among various game engine supported, Unity is the most up to date runtime including the most recent features, many samples, integrating well in the Unity editor.
Pro Easy to use
Creature has a simple workflow structured into 3 steps: Meshing, Rig and Animate.
Cons

Con No longer under development
The most recent update to Denima occurred in October 2012.

Con XNA-specific
Denima's runtime library is intended to integrate with the XNA framework, which has been unsupported since April 2014.
