When comparing Trillian vs Smuxi, the Slant community recommends Smuxi for most people. In the question“What are the best IRC clients for Windows?” Smuxi is ranked 20th while Trillian is ranked 22nd. The most important reason people chose Smuxi is:
It's possible to check and interact with Twitter's timeline, replies and direct messages from the Smuxi client.
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Pros
Pro In-house server support
You can set up a dedicated server to hold your communications. Great for businesses that want to build their own infrastructure.
Pro Multiple networks in one place
Among them Yahoo!, Facebook, Skype, Google, AIM, ICQ, XMPP, MSN. You can have multiple accounts associated with each service.
Pro Group chat
Trillian to Trillian group chat is available.
Pro Twitter integration
It's possible to check and interact with Twitter's timeline, replies and direct messages from the Smuxi client.
Pro Distributed
Smuxi offers an option to keep idling in a channel even when all front-end clients are closed. It's possible for a front-end client or multiple front-end clients to connect to a single server. This allows setting up an always on-line server that can be accessed from anywhere.
Pro Plugins and scripts can be written in any language
Pro Highly customizable interface
Pro Facebook chat, gTalk and Jabber integration
Smuxi has XMPP protocol support that allows integrating with Facebook chat, gTalk and Jabber.
Pro Theming support
Pro Caret mode
Caret mode allows navigating through messages (the output buffer) via keyboard.
Cons
Con Supports all dead services.
Con Poor script and plugin library
Smuxi's script and plugin library contains less than 10 entries.
