When comparing pyglet vs CRM32Pro SDK, the Slant community recommends pyglet for most people. In the question“What are the best 2D game engines?” pyglet is ranked 44th while CRM32Pro SDK is ranked 92nd. The most important reason people chose pyglet is:
Since pyglet is so tightly woven with OpenGL it allows the support of drawing in 3D.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro 3D support
Since pyglet is so tightly woven with OpenGL it allows the support of drawing in 3D.
Pro Cross-platform
Works with Windows, Linux, and OS X.
Pro Written in pure Python
A small advantage, but being a core Python developer, it may be the best to stick to the roots and develop with pyglet as it is able to compile using other Python interpreters.

Pro Great tools included
EditorDPF: resource editor for managing images, tiles, sprites, sounds, etc. of your game
MSTE: tile-based parallax scrolling engine with support to Tiled Qt .TMX files
SetupProject: customized configuration system.

Pro Cross-platform
CRM32Pro works on Windows, Linux and MacOS X.

Pro Open source and free
CRM32Pro is licensed under LGPL license with full access to the source code on the website.
Cons
Con Small community/popularity
There is a decent amount of documentation and API to go along with pyglet, but in terms of community support there seems to be very little.
Con Not as beginner friendly
C/C++ skills and general knowledge of SDL and basic game programming is required in order to get all the benefits.
