When comparing pyglet vs Leadwerks Game Engine, the Slant community recommends pyglet for most people. In the question“What are the best 2D game engines?” pyglet is ranked 44th while Leadwerks Game Engine is ranked 74th. The most important reason people chose pyglet is:
Since pyglet is so tightly woven with OpenGL it allows the support of drawing in 3D.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro 3D support
Since pyglet is so tightly woven with OpenGL it allows the support of drawing in 3D.
Pro Cross-platform
Works with Windows, Linux, and OS X.
Pro Written in pure Python
A small advantage, but being a core Python developer, it may be the best to stick to the roots and develop with pyglet as it is able to compile using other Python interpreters.

Pro Versatile flow diagram script model
Leadwerks's flowgraphs resemble flowcharts where each box represents a function or value, with connections between them representing program flow. This provides a better at-a-glance indication of game logic than a simple list of events, and makes complex behaviors easier to accomplish.
Pro Built-in level editor
Has an acceptable 3D map editor that is easy to use.
Pro Handful of Prefabs and Scripts
For example, you take a model (e.g. torch), add a light source to it, add a particle generator (for fire) and save it as a prefab (one file). Then this prefab can be used to add many torches with fire and light.
Cons
Con Small community/popularity
There is a decent amount of documentation and API to go along with pyglet, but in terms of community support there seems to be very little.
Con Very buggy
Leadworks is a not complete, it's a work in progress. As such many parts of the engine are clunky, especially the level editor.

Con Documentation and support are limited for non-coders
The flowgraph editor can be used with free script assets to build games without writing any code, but this is not directly intended or encouraged by Leadwerks.
Con Highly misleading advertising
