When comparing Tiled vs Spine, the Slant community recommends Spine for most people. In the question“What are the best 2D animation tools for game development?” Spine is ranked 2nd while Tiled is ranked 9th. The most important reason people chose Spine is:
Spine provides integrated modules for 14 major engines including GameMaker Studio, Cocos2Dx, LOVE, MonoGame, Unity, XNA, Flash, HTML 5, libgdx, Corona, and more. Generic runtime libraries are also available for C, C++, Objective C, C#, JavaScript, Lua and ActionScript 3. Dozens of third party libraries support additional targets.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Multi-platform
Not everyone uses the same operating system and why should they? Tiled supports Windows, Mac, and Linux so you can work in any environment you like. Also with daily builds you get to stay ahead of the curve!
Pro Free and open-source
Using the GPL license means you get to use this software free and are free to make changes to it as you see fit.
Pro Unlimited layers
Sometimes you need 20 layers to make something epic. Tiled lets you create as many layers as you need.
Pro Use shell commands
Setup shell commands within Tiled so you can setup workflows for each of your games.
Pro Supports Orthographic and Isometric tiles
Whether you want a straight on look at your world or a slightly skewed one Tiled has you covered.
Pro Terrains
Setup boarders with your tilesets so making tiles provide the correct connections automatically. This feature will speed up your level creation.
Pro Auto-mapping
One of the coolest things is to create rules so you can automate the mapping process. Want to have certain tiles to always have a collider? Simply make a rule for it and it'll do it automatically. Speed up your mapping process with this feature.
Pro Many engines already have support
A big list of engines already have support for Tiled provided by those in the community. See if the engine you use is already on the list.
Pro Can create colliders and triggers within editor
Tiled makes it easy to setup triggers and colliders with its vector tools or you can set up a tile that’s invisible in your game. Change collider/trigger properties so you can access them within your game.
Pro Tile size and image size do not have to match
Want to import a giant object but don’t want to split it up? Import it and place it the exact size you want it as one object.
Pro Properties
Create properties for your map, layers, tilesets, tiles, and objects. Have the flexibility you need to create the best levels for your game.
Pro Engine agnostic
Tiled provides an easy solution for tile maps for any engine even the custom engine you are now making. This makes Tiled a very versatile tool for 2D games.

Pro Integration libraries support most engines
Spine provides integrated modules for 14 major engines including GameMaker Studio, Cocos2Dx, LOVE, MonoGame, Unity, XNA, Flash, HTML 5, libgdx, Corona, and more. Generic runtime libraries are also available for C, C++, Objective C, C#, JavaScript, Lua and ActionScript 3. Dozens of third party libraries support additional targets.
Pro Simplified UI allows for an easy learning curve
No-nonsense workflow allows you to create your artwork in programs much better suited for the task like Illustrator and Inkscape for example, while Spine itself focuses only on the important task of skeletal animation.
Pro Allows for easy use of artwork from third party programs
Spine's developers provide scripts which makes exporting artwork from third party programs much easier to do.

Pro Community-driven feature roadmap
Esoteric Software maintains public Waffle issue trackers to help plan and prioritize feature additions.

Pro Funded via Kickstarter
Spine received resounding support from Kickstarter backers, beating its pledge goal by over 5 times. A second successful Kickstarter added meshes and other important features.
Pro Price high for this product
Cons
Con Must implement .tmx if your engine doesn’t support Tiled.
It’s not a huge deal but you do need to implement Tiled into your engine if you don’t have it. Don't be lazy just follow this guideline to get your game running. Must implement .tmx if your engine doesn’t support Tiled.
Con Spine Professional is expensive
Spine Essential includes nearly all features, except IK, weights, and meshes. Spine Professional is expensive, though it does give all future updates for life (Spine is updated very often).
Con Requires EVERY developer to have a license
Ever developer needs a license, not just the animator, or an overall license for the project. The license agreement is extremely restrictive.
Con Doesn't support gamemaker 2.3
Con No integration for lesser known engines
Spine does not directly support some game engines, such as Construct 2 or Clickteam Fusion.
