When comparing Puppet2D vs Creature, the Slant community recommends Creature for most people. In the question“What are the best 2D animation tools for Unity?” Creature is ranked 5th while Puppet2D is ranked 7th. The most important reason people chose Creature is:
One of Creature's strengths is its ability to assign motors on bones which will generate animations based on parameters set on the motors.
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Pros
Pro Mesh Deformation
Instead of having to change sprites to bend legs or other joints mesh deformation changes the mesh shape based on joint weights to bend and move.

Pro Inverse Kinematic bones
Bones will move and rotate reacting to the position of the rest of the skeleton. The animator does not have to animate each part of a joint but rather have it follow realistically. Also can be used for ragdoll effects based on physics.
Pro Built on top of Unity’s animation system
Mecanim and state machines work natively since Puppet2D builds on top of Unity’s built in animation system.
Pro Automated animation
One of Creature's strengths is its ability to assign motors on bones which will generate animations based on parameters set on the motors.
Pro Unity runtime always up to date
Among various game engine supported, Unity is the most up to date runtime including the most recent features, many samples, integrating well in the Unity editor.
Pro Easy to use
Creature has a simple workflow structured into 3 steps: Meshing, Rig and Animate.
Cons

Con Forced editor scaling causes problems
Puppet2D adjust the scaling of bones in the editor for display purposes, which results in unintended behavior if other objects use a bone as a parent.
