Pandemic Legacy is a co-op campaign board game. You play as a team of specialists who try to stop four diseases from spreading around the world. The main story is played in 12-24 sessions, depending on how well your group performs. The game begins very similar to the basic Pandemic game, and has many of the same rules.
While similar, Legacy varies from the base game Pandemic in several notable ways. Certain game components will be permanently altered - this includes writing on cards, ripping up cards, and putting stickers on components. Additionally, your characters can now gain new skills or even suffer detrimental effects.
Each player chooses a role (scientist, researcher, pilot, etc) which gives them special abilities and make certain actions more beneficial. During each turn, you will have four actions available - travel, building structures, treating diseases, or find a cure. After each turn, you will draw two cards. These cards may be an epidemic card which places new diseases on the board or spreads already existing diseases to a new city. The game ends when all diseases are eradicated from the board.
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Pros
Pro Very high short-term replayability due to the persistent story in the game
With individual plays regularly ending in teasers and cliffhangers players will be eager to play the next round in order to move the story forward and find out what happens next.
Pro A persistent campaign means that your descisions have consequences, both good and bad, in future games
Pandemic Legacy is the latest in the Legacy line of games where things that happen in one game can, and often do, have affects in later games. The characters you use can gain new abilities and or flaws, components can be added and/or destroyed and rules can be added, amended, or removed, all based on the things that you do from game to game. This helps players feel invested in the game and makes their decisions even more meaningful than they already were. This ongoing change also means that your experiences may very well be unique to your group and that other campaigns of the same game will go drastically different, with only main plot points in common.
Cons
Con No long-term replayability
After the main campaign is finished (12-24 games) the game is mostly finished. Technically you can play the final mission over and over, but permanent changes made over the course of the playthrough, such as stickers added to the rules, board, and player sheets as well as components that are physically destroyed make the game less fun to replay after the main story concludes.
Con Requires a commited group to play and experience the full extent of the game
Pandemic: Legacy games are meant to be experienced over 12-24 games with the same players so that everyone involved can share in the overarching story of the game. Unfortunately, many gamers may struggle to find 2-4 players that can regularly meet up to play the game, making it difficult to finish the main story.