When comparing RPGMaker vs uScript + Unity3D, the Slant community recommends RPGMaker for most people. In the question“What are the best 2D game engines?” RPGMaker is ranked 28th while uScript + Unity3D is ranked 97th. The most important reason people chose RPGMaker is:
It's possible to create a game with absolutely no art or coding skills, so even complete beginners can make something.
Specs
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Pros
Pro Easy to jump into using an intuitive WYSIWYG editor
It's possible to create a game with absolutely no art or coding skills, so even complete beginners can make something.
Pro Large and active community
The engine has seen multiple iterations since 1995, so a large online community exists that is always willing to help each other out.
Pro Ruby / Javascript support provides depth to more experienced developers
With a script editor that uses a modified version of Ruby, it's possible to go well beyond the traditional RPG with this engine. Note: XP and VX use Ruby, the latest version "MV" uses Javascript for scripting.
Pro It's an open engine
It's possible to use custom editors from the community, edit libraries,include libraries,etc (MV Only)
Pro Multi-platform
MV supports HTML5 exports, so it is easier than ever to make your game work on iOS, android, OSX,Linux or Windows.
Pro Inbuilt database and multplayer plugins, providing you the scalfolding to customising your projects with ease
The inbuilt database which binds to game saves or can be made persist allows great power within your logic. Also a plugin called 'Alpha.net' provides multiplayer. This combination can allow great customisation of the engine, allowing a powerful 2D game to be made with little to no coding experience.
Pro Greater Map layers
MV Mapping uses an additional layer to create better depth.
Pro MV has HTML5 export
You can now HTML5 export your projects, so you could theoretically host your game on your webserver, and have your friends play the game without ever having to install a single thing.
Pro A cheap license that allows using the software commercially
There are several versions of RPG maker, with MV being the latest and most fully featured: MV ($79.99), VX Ace ($69.99), VX ($59.99) and XP ($24.99), 2003 ($19.99).

Pro Automatically generates nodes for third-party script assets
uScript's nodes are a visual representation of actual code blocks, and it takes advantage of C#'s reflection capabilities to automatically create nodes for any scripts it finds in your project, regardless of the source. This makes it inherently compatible with pretty much everything.
Custom nodes can also be created by hand, for cases where the automatically created ones contain more elements than they actually need.

Pro Versatile flow diagram script model
Modeled after UDK's Kismet (the predecessor to UE4's Blueprint), uScript's scripts resemble flowcharts where each box represents a function or value, with connections between them representing program flow. This provides a better at-a-glance indication of game logic than a simple list of events, and makes complex behaviors easier to accomplish.

Pro Generates C# source code
Nodes are translated directly to C# files in your project. This is great for learning to code, and also for advanced users who can use uScript for fast prototyping and then further optimize the scripts if necessary.
Cons
Con You have to code when you want something didn't built in
You know,RM series' default walk animation only has three frames.If you want to enhance,you have to code by yourself——especially majority of it's user are newbies.
Con No Hardware accelerate
You'll get a bad performance when you have big animations,especially in MV,which can easily change into higher resolution.
Con No 3D support
None of them have 3D support, it is possible only with manual scripting which could be difficult for beginners.
Con MV Does not have a "REAL" Android export.
MV has an export to HTML5 - which can run on any browser including android. It is however not a "native" app export.
Con Inconsistent included visual assets
Included visual assets within MV have inconsistent presentation. Though RPMMV does contain enough to make a small basic title, the visual assets don't often look like they should be mixed on-screen.
Con No built-in realtime battle system
RPG Maker series has only turn based battle systems, unless scripts/Plugins made by the community are used.
Con Conversion to MV difficult
Older iterations of RPG Maker use smaller sprite sizes that require manual conversion to use older RTP assets and older assets are more robust.

Con Not that easy to use
It's a lot more complicated compared to something like Playmaker. Same tasks take a lot more time.
