When comparing Unity 2D vs PureBasic, the Slant community recommends Unity 2D for most people. In the question“What are the best 2D game engines?” Unity 2D is ranked 7th while PureBasic is ranked 40th. The most important reason people chose Unity 2D is:
2D game creation was a major feature request from the Unity community and was added with version 4.3. 2D is provided in both the Pro and Free distribution of Unity.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Built into Unity 4.3+
2D game creation was a major feature request from the Unity community and was added with version 4.3. 2D is provided in both the Pro and Free distribution of Unity.
Pro Integrates with Mecanim
Mecanim brings state machines and blending to 2D bone animation. The state machine editor allows for designers and programmers to visually create a Finite State Machine (FSM) to control when animations should play. Mecanim also allows for blending so an animation can transition smoothly between two states without the need of in between frames made by an animator.
Pro Sprite Sheet and Bone based animation supported
Both types of 2D animation for game development are supported in Unity’s system and can be used interchangeably in the timeline.
Pro Easily change sprites dynamically
Usually used for character customization, programmers can change any sprite in a bone animation at runtime easily by referencing the bone and loading the new sprite from the resources folder.
Pro Standalone executables
Can create single file executables without the need to install other libraries, run time environments, etc.
Pro The syntax is very beginner-friendly
Pro Same code on Windows, OS X and Linux
Same code can be compiled natively, without any interpreter for OS X, Windows or Linux, using the native GUI toolkit of the OS
Pro Many integrated features
Many libraries available without additional installations : 2D & 3D, database, network, sound, xml, JSON, http...
Pro Allows to program at a lower level than most alternatives
Pro Lifetime license
Pay once, use forever.
Pro Constantly updated
Pro Supports ARM in addition to x86, AMD64 and others
Pro Can compile to plain C code
Pro Grest user community / forums with the developer very active
Cons
Con Lacks critical features
- Vertices can't be animated, so you can't have ANY organic feel (like... lungs breathing).
- Parent bone can't be animated without affecting the children. This is especially impeding for organic feel, again.
- No option to show & unshow assets (or it is hidden), like for switching weapon on your character for exemple.

Con Poor script interface for texture atlases
Accessing individual sprites within an atlas texture is possible at runtime, but requires use of the Resources folder subsystem.
Con Limited free version
Free version is limited to 800 lines and can not create DLL's.
Con Some bugs are present on the Linux platform
Con Slightly bogged syntax
Sometimes the syntax bogs down, just a little with long procedure names and such. A truly minor issue.
Con Not RAD
Not a RAD environment.
