When comparing GameMaker: Studio vs Blender, the Slant community recommends GameMaker: Studio for most people. In the question“What are the best game engines for beginners and non-programmers?” GameMaker: Studio is ranked 6th while Blender is ranked 10th. The most important reason people chose GameMaker: Studio is:
Game Maker Language (GML) is the primary scripting language that is interpreted similarly to Java's Just-In-Time compilation used in GameMaker. It is used to further enhance and control the design of a game through more conventional programming, as opposed to the drag and drop system.
Specs
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Pros
Pro Gives developers access to a more fine-grained controle over the logic through the Game Maker Language
Game Maker Language (GML) is the primary scripting language that is interpreted similarly to Java's Just-In-Time compilation used in GameMaker. It is used to further enhance and control the design of a game through more conventional programming, as opposed to the drag and drop system.
Pro Extremely easy to learn
GameMaker: Studio is incredibly easy to learn. It requires almost no programming knowledge which means that those without the technical experience, such as designers or artists, can create their projects without the help of a programmer.
Pro Easy to find resources/tutorials/assistance
GameMaker: Studio has a huge following, tons of people put up tutorial videos, and it's just generally easy to find help. It has a huge community.

Pro Easy cross-platform shader support
Write your own shaders in one shader language and have it automatically ported to all platforms. You can even choose a specific shader language to wield the full power of the target device.
Pro Assets can easily be found in the official marketplace
Yoyogames website has a marketplace which opens up an opportunity for people to sell or giveaway created assets and resources (sprites, scripts, sounds, extensions, full source codes, etc.) for use in GameMaker. This benefits people who needs quality assets for their games, and for creative people to provide these assets for extra income. The Marketplace has a rating system so it can eventually increase the quality and competitiveness of the assets submitted.
Pro It has an IDE used for loading all of the assets
It is very easy to manage all the resources you want to put in your game, the UI widgets for each assets (sprites, sounds, backgrounds, rooms, objects and shaders) are intuitive enough for when adding or even editing the properties of each your assets. The included editors are also good and easy to use (sprite/image editors, shader editor and room editor).
Pro Extremely stable
GameMaker: Studio has been around since 1999 and has been used and maintained during all this time. This makes it an extremely stable game engine.

Pro Cross-platform multiplayer support
There is the possibility of creating games that interact with different platforms and is not that hard.
Pro Built-in support for pixel-perfect collisions
Enabling pixel-perfect collisions on 2D sprites is so easy many will likely turn it on when maybe they might be better off without it. Regardless, it simplifies small and/or retro console-like game work. This is a feature fairly unique in this class of game engines.
Pro Cross-platform
GameMaker: Studio projects can be deployed to: HTML5, Linux, Windows, OS X, Windows Phone, Android, iOS and PS3/4/Vita.
Pro Easy to use
Game Maker Studios simple interface allows for rapid prototyping, and easy development.

Pro Supports 3D
There is also 3D support that doesn't interfere with the primary 2D focus.
Pro Easy to add native code to GMS
Good extension support. You can do anything with gms! You just need to know how to code natively in the respectively export (like Android).


Pro Free and open source
Blender is licensed under the GPL. Some Blender modules such as the Cycles rendering engine are licensed under the Apache 2.0 license.

Pro Wide import and export format support
Support lots of modern 3D formats including DAE and FBX - ideal for game developers.
Pro Has a powerful rendering engine
Blender runs the Cycles path tracing engine under the hood. Cycles is a very powerful rendering engine capable of full path tracing (light fall off, caustics, volumetrics). It is mostly compatible with OpenCL and CUDA rendering, and is implementing mycropolygon displacement features. The upcoming release has a viewport engine called EEVEE whereby you can see and interact with your work in render mode in real time!

Pro Python extensibility
Blender embeds Python 3, which can be used to write add-ons, tools, extend the interface, rig characters and automate tasks.

Pro Powerful animation suite
Blender provides a full rigging system, and automates animation by interpolating between keyframe positions.
Pro Supports both low-poly and hi-poly modeling

Pro Regular release schedule
Releases are made every ~3 months.
Pro Sculpting and 3D painting features
Although Blender's 3d painting and sculpting tools (mostly painting) are not at par with specialized software like Substance Painter, ZBrush, or Mari, it is more than capable of getting most jobs done if the user takes the time to learn and understand it.

Pro Includes video editing & compositing tools
Blender's node-based compositor has comprehensive video sequencing and post-processing features.
Pro Node based modeling support
Pro Keyboard shortcuts
Good keyboard shortcuts for everything. Keep your left hand on the keyboard and your right hand on the mouse.
Pro Very useful for a freelancer
It offers a round solution (it covers many areas and professional fields) for a freelancer, for free, constantly updated, very polished, and allowing high quality results that clients do require. After some learning, it becomes very useful for professional work.
Pro Has a large community
There's a huge community to help you get started immediately.
Pro Coherent and streamlined workflow / internal use logic
The trick with Blender is to get used to its usage philosophy, as it keeps consistent through all the application. Once you get it, every feature or addition is learnt naturally, almost effortlessly.
Pro Very versatile
You don't have to switch between software when you want to do different things. Because modeling, sculpting, composting, video editing etc can all be done in blender.
Pro Generative geometry using nodes
Cons
Con The scripting language used is quite limited
Language does not support actual objects, structs, real data types, functions, overloading, even argument naming. Developers generally have to code around the lack of these features in very tricky ways.
Con No GUI editor
The GUI must be hard-coded, leaving a lot of tricky calculations and jumping through hoops to accommodate different devices and displays; it's probably the least developed and hardest thing about GMS2 compared to comparable engines

Con Destructive DRM
In late 2012/early 2013, YoYo Games released a version of their new Studio IDE for cross-platform development that would import games and destroy all of the image type resources for some legitimate purchasers of the software by superimposing a pirate symbol on top of the image. This was due to a fault in their digital rights management software implementation which they use as a method of combating pirated copies of the software. Though the false positives bug is reported to be fixed, the DRM is still in place and may affect placeholder graphics, etc. YoYoGames publicly stated they would remove the DRM at a later point in time, but that other less-invasive DRM techniques would remain.
Con Exporting to some formats costs extra
You need to buy extra modules to be able to export to platforms like Android, iOS, HTML5 and others.
Con No built-in refactoring tools
There are no built-in refactoring tools. For example, you can rename a resource, but GM:S will not automatically change the mentions of it across the code to the new name. Furthermore, because all file formats are text-based, basic refactoring could be achieved by simply doing "find & replace in all files" -- which is a feature offered by pretty much every external code editor nowadays -- but no such feature here. Hitting Ctrl-F will pull up a rather odd Find/Replace box but selecting a word before hitting Ctrl-F will not autofill the Find field for you like it will in most tools. Even that you have to cut and paste yourself.
Con The cost to buy for development is outrageous
The cost for this tool is hindering for indie developers who have little money to work with.
Con Bad history of ignoring critical bugs
In the past, the developer failed to update the software for iOS and Android when game-breaking updates were made to those platforms.
Con Development has been and will be cosmetic
The change from 1.x to 2.x was cosmetic, the engine and language stayed the same. The roadmap for future development is also cosmetic and includes updating the sprite editor, adding an audio editor, and adding a "mini map" for the IDE.

Con Poor level editor
No marquee select, no layers, can be glitchy, no grouping, etc.
Con Can't embed videos in game
Doesn't support embedding videos in a game.
Con Expensive for what it offers
There are several options with more flexibility, better learning resources, and a lower price point.
Con Proprietary language forces expensive "lock in"
Because it uses GML, a very non-standard custom language, new users do not learn a transferrable language and become locked in.
Con Tends to crash or not compile games properly
Con Poor accessibility and integration
Documentation and resources largely focus on proprietary scripting language, which is necessary for achieving full potential of the software due to poor drag and drop integration.
Con No way to activate or use existing modules
Support entirely focused on new iteration depriving even basic functionality of this version with any purchase that hasn't already been activated. It is still possible, thought not intuitive, to download this version on the trail screen for GM S 2. But no purchased (wildly expensive) module can be added any longer.
Con Code editor not friendly to indented code
While the editor of course has features for intending code such as auto indent and smart tabs that can be turned on or off, these features work in unusual ways and, overall, the editor is not very adaptable to various typing styles. Also, Home always takes you to position 0 and never to the beginning of the text no matter how many times you hit it. Thus, if you hit Home and then Enter a new line, with auto indent on, it will always mess up the indentation on the line following the new line leaving you to fudge around to fix it manually. If you prefer tabs over spaces, forget it. Finally, if you leave the GameMaker app and try to click back into the code editor, the code editor will not fully get the focus sometimes leaving you with the ability to type but not tab. It usually takes two clicks to fully focus the code editor from outside the GM app.
Con This is very flat for games
They are not beautiful - for example, Undertale.
Con Owned by a gambling company, Playtech
As opposed to other engines, which are open source or owned by game companies, GameMaker is developed by YoYoGames, which is owned by Playtech, a gambling software company.
Con Too many possibilities, no unified workflow
The operations are not optimized enough for specific tasks.
Con The physics engine is a bit lagging behind, especially the destruction physics
Con Difficult learning curve
Blender has a history of being unintuitive, but the 2.8 overhaul made the program far easier for beginners to pick up, and changes continue to be made to further improve the experience. However, there is still a learning curve.
Con Not good for Industrial Design because it uses average vertex normals
You can not create a hard surface with a radius continuity degree along a surface using a specific radius value.
Con Vertex normal issues on edges after boolean operations.
After creating a simple boolean operation the vertex normals are broken. A lot of work to fix the issue and you loos surface continuity.
Con Bad vertex normal after boolean operations
Does not handle well polygon intersections. And need tweaking by hand points or adding average vertex normals via modifiers.
Con Does not handle NURBs
Is not capable of real hard surface for industrial design because is not able to reproduce surface continuity degree as a NURBs does and average vertex normal destroy surface radius.
Con Poor particle system
The Blender particle system can at times be a little limiting and finicky (and buggy) to get working. Even if it can get most straight forward jobs done, it is far from the most advanced system, and could benefit largely from advancements.
