When comparing RPGMaker vs Unity 2D, the Slant community recommends Unity 2D for most people. In the question“What are the best 2D game engines?” Unity 2D is ranked 7th while RPGMaker is ranked 28th. The most important reason people chose Unity 2D is:
2D game creation was a major feature request from the Unity community and was added with version 4.3. 2D is provided in both the Pro and Free distribution of Unity.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Easy to jump into using an intuitive WYSIWYG editor
It's possible to create a game with absolutely no art or coding skills, so even complete beginners can make something.
Pro Large and active community
The engine has seen multiple iterations since 1995, so a large online community exists that is always willing to help each other out.
Pro Ruby / Javascript support provides depth to more experienced developers
With a script editor that uses a modified version of Ruby, it's possible to go well beyond the traditional RPG with this engine. Note: XP and VX use Ruby, the latest version "MV" uses Javascript for scripting.
Pro It's an open engine
It's possible to use custom editors from the community, edit libraries,include libraries,etc (MV Only)
Pro Multi-platform
MV supports HTML5 exports, so it is easier than ever to make your game work on iOS, android, OSX,Linux or Windows.
Pro Inbuilt database and multplayer plugins, providing you the scalfolding to customising your projects with ease
The inbuilt database which binds to game saves or can be made persist allows great power within your logic. Also a plugin called 'Alpha.net' provides multiplayer. This combination can allow great customisation of the engine, allowing a powerful 2D game to be made with little to no coding experience.
Pro Greater Map layers
MV Mapping uses an additional layer to create better depth.
Pro MV has HTML5 export
You can now HTML5 export your projects, so you could theoretically host your game on your webserver, and have your friends play the game without ever having to install a single thing.
Pro A cheap license that allows using the software commercially
There are several versions of RPG maker, with MV being the latest and most fully featured: MV ($79.99), VX Ace ($69.99), VX ($59.99) and XP ($24.99), 2003 ($19.99).
Pro Built into Unity 4.3+
2D game creation was a major feature request from the Unity community and was added with version 4.3. 2D is provided in both the Pro and Free distribution of Unity.
Pro Integrates with Mecanim
Mecanim brings state machines and blending to 2D bone animation. The state machine editor allows for designers and programmers to visually create a Finite State Machine (FSM) to control when animations should play. Mecanim also allows for blending so an animation can transition smoothly between two states without the need of in between frames made by an animator.
Pro Sprite Sheet and Bone based animation supported
Both types of 2D animation for game development are supported in Unity’s system and can be used interchangeably in the timeline.
Pro Easily change sprites dynamically
Usually used for character customization, programmers can change any sprite in a bone animation at runtime easily by referencing the bone and loading the new sprite from the resources folder.
Cons
Con You have to code when you want something didn't built in
You know,RM series' default walk animation only has three frames.If you want to enhance,you have to code by yourself——especially majority of it's user are newbies.
Con No Hardware accelerate
You'll get a bad performance when you have big animations,especially in MV,which can easily change into higher resolution.
Con No 3D support
None of them have 3D support, it is possible only with manual scripting which could be difficult for beginners.
Con MV Does not have a "REAL" Android export.
MV has an export to HTML5 - which can run on any browser including android. It is however not a "native" app export.
Con Inconsistent included visual assets
Included visual assets within MV have inconsistent presentation. Though RPMMV does contain enough to make a small basic title, the visual assets don't often look like they should be mixed on-screen.
Con No built-in realtime battle system
RPG Maker series has only turn based battle systems, unless scripts/Plugins made by the community are used.
Con Conversion to MV difficult
Older iterations of RPG Maker use smaller sprite sizes that require manual conversion to use older RTP assets and older assets are more robust.
Con Lacks critical features
- Vertices can't be animated, so you can't have ANY organic feel (like... lungs breathing).
- Parent bone can't be animated without affecting the children. This is especially impeding for organic feel, again.
- No option to show & unshow assets (or it is hidden), like for switching weapon on your character for exemple.

Con Poor script interface for texture atlases
Accessing individual sprites within an atlas texture is possible at runtime, but requires use of the Resources folder subsystem.
